202 research outputs found
Herding Effect based Attention for Personalized Time-Sync Video Recommendation
Time-sync comment (TSC) is a new form of user-interaction review associated
with real-time video contents, which contains a user's preferences for videos
and therefore well suited as the data source for video recommendations.
However, existing review-based recommendation methods ignore the
context-dependent (generated by user-interaction), real-time, and
time-sensitive properties of TSC data. To bridge the above gaps, in this paper,
we use video images and users' TSCs to design an Image-Text Fusion model with a
novel Herding Effect Attention mechanism (called ITF-HEA), which can predict
users' favorite videos with model-based collaborative filtering. Specifically,
in the HEA mechanism, we weight the context information based on the semantic
similarities and time intervals between each TSC and its context, thereby
considering influences of the herding effect in the model. Experiments show
that ITF-HEA is on average 3.78\% higher than the state-of-the-art method upon
F1-score in baselines.Comment: ACCEPTED for ORAL presentation at IEEE ICME 201
LOWER EXTREMITY JOINT KINETICS DURING LANDING OF A DROP JUMP FROM DIFFERENT HEIGHTS AND LANDING SURFACES
This study aimed to investigate the biomechanical effect of the lower extremity joints from a vertical fall of 30 cm and 60 cm to a soft mat and a stiff floor respectively. Result shows, from either height, the joint forces and peak joint moments decrease significantly, while the joint angles changes to a greater degree when landing on a soft mat and it needs more time from initial contact till the action stops. 'Each joint moment is effect of external moment and internal muscle moment together. The correct landing technique is that moments of all joints reduce simultaneously, Le. the contraction and passive extension of muscles should be controlled in sequence and magnitude. The highest muscle moment on contact landing is observed at hip joint on 'both landing conditions and the muscles of the knee and ankle joints guided by the hip muscles assist each other
Human Gait Database for Normal Walk Collected by Smart Phone Accelerometer
The goal of this study is to introduce a comprehensive gait database of 93
human subjects who walked between two endpoints during two different sessions
and record their gait data using two smartphones, one was attached to the right
thigh and another one on the left side of the waist. This data is collected
with the intention to be utilized by a deep learning-based method which
requires enough time points. The metadata including age, gender, smoking, daily
exercise time, height, and weight of an individual is recorded. this data set
is publicly available
STGIN: Spatial-Temporal Graph Interaction Network for Large-scale POI Recommendation
In Location-Based Services, Point-Of-Interest(POI) recommendation plays a
crucial role in both user experience and business opportunities. Graph neural
networks have been proven effective in providing personalized POI
recommendation services. However, there are still two critical challenges.
First, existing graph models attempt to capture users' diversified interests
through a unified graph, which limits their ability to express interests in
various spatial-temporal contexts. Second, the efficiency limitations of graph
construction and graph sampling in large-scale systems make it difficult to
adapt quickly to new real-time interests. To tackle the above challenges, we
propose a novel Spatial-Temporal Graph Interaction Network. Specifically, we
construct subgraphs of spatial, temporal, spatial-temporal, and global views
respectively to precisely characterize the user's interests in various
contexts. In addition, we design an industry-friendly framework to track the
user's latest interests. Extensive experiments on the real-world dataset show
that our method outperforms state-of-the-art models. This work has been
successfully deployed in a large e-commerce platform, delivering a 1.1% CTR and
6.3% RPM improvement.Comment: accepted by CIKM 202
Investigation of CYP1B1 mutations in Chinese patients with primary congenital glaucoma
Purpose: This study was conducted to investigate the mutation spectrum of the cytochrome P450 gene (CYP1B1) in Chinese patients with primary congenital glaucoma (PCG). Methods: The coding regions of CYP1B1 from 41 Chinese PCG patients were analyzed using polymerase chain reaction (PCR) and heteroduplex analysis-single strand conformation polymorphism (HA-SSCP) followed by subsequent cloning and bidirectional sequencing. New variants were confirmed by restriction fragment length polymorphism (RFLP) analysis in 80 normal Chinese controls. Results: Six distinct mutations, four of which are novel, were identified in 14.6 % (6/41) of all patients. The CYP1B1 mutations in two patients were homozygous, and the other four patients were compound heterozygous. Beyond the four novel mutations (g.4531_4552del22bp, g.4633delC, p.S336Y, and p.I471S), two reported missense mutations (R469W and R390H) were also identified. The missense mutation, R390H, was involved in 9.8 % (4/41) of patients in our study. None of the novel mutations was observed in any of the 80 controls. Conclusions: Our results support the premise that CYP1B1 is a major gene for PCG, appearing to be responsible for the disease in roughly one in six Chinese PCG patients. The R390H mutation was identified as a predominant CYP1B1 allele among the Chinese PCG patients in our study. This observation emphasizes the importance of mutational screening of CYP1B1, especially for the R390H mutation in Chinese patients
Indoleamine 2,3-Dioxygenase Immune Status as a Potential Biomarker of Radioiodine Efficacy for Advanced Distant Metastatic Differentiated Thyroid Cancer
PurposeHost immunity influences the impact of cancer therapy but the effect of immune status in radioiodine (RAI)-treated differentiated thyroid cancer (DTC) remains obscure. Here we investigated indoleamine 2,3-dioxygenase (IDO) activity as a biomarker of response to RAI in patients with distant metastatic DTC (dmDTC).MethodsPatients with dmDTC receiving RAI were evaluated for serum IDO activity (kynurenine and kynurenine:tryptophan ratio) at baseline and 3 months after RAI. The optimal cut-off value for these biomarkers to predict response was established by receiver operating characteristic analysis. The relationship between disease outcomes, overall survival (OS) and progression-free survival (PFS), and IDO activity levels was studied.ResultsHigher baseline kynurenine:tryptophan ratio (>2.46) was correlated with poorer RAI response as well as shorter median PFS (45 mo versus not reached, p=0.002) and OS (78 mo versus not reached, p=0.035). High baseline kynurenine:tryptophan ratio was also correlated with a reduced number of tumor-infiltrating lymphocytes. Higher post/pre-kynurenine ratio (>1.69) was associated with survival endpoints: shorter median PFS (48 mo versus not reached, p=0.002) and OS (68 mo versus not reached, p=0.010). Favorable baseline and favorable change corresponded with better PFS and OS.ConclusionsOur results suggest that RAI also alters IDO activity in dmDTC patients. IDO activity could predict progression and survival outcomes for advanced dmDTC patients. Serum IDO biomarker levels could be used to select dmDTC likely to benefit from RAI therapy, although further studies are necessary
Bayesian multimodel estimation of global terrestrial latent heat flux from eddy covariance, meteorological, and satellite observations
Accurate estimation of the satellite-based global terrestrial latent heat flux (LE) at high spatial and temporal scales remains a major challenge. In this study, we introduce a Bayesian model averaging (BMA) method to improve satellite-based global terrestrial LE estimation by merging five process-based algorithms. These are the Moderate Resolution Imaging Spectroradiometer (MODIS) LE product algorithm, the revised remote-sensing-based Penman-Monteith LE algorithm, the Priestley-Taylor-based LE algorithm, the modified satellite-based Priestley-Taylor LE algorithm, and the semi-empirical Penman LE algorithm. We validated the BMA method using data for 2000–2009 and by comparison with a simple model averaging (SA) method and five process-based algorithms. Validation data were collected for 240 globally distributed eddy covariance tower sites provided by FLUXNET projects. The validation results demonstrate that the five process-based algorithms used have variable uncertainty and the BMA method enhances the daily LE estimates, with smaller root mean square errors (RMSEs) than the SA method and the individual algorithms driven by tower-specific meteorology and Modern Era Retrospective Analysis for Research and Applications (MERRA) meteorological data provided by the NASA Global Modeling and Assimilation Office (GMAO), respectively. The average RMSE for the BMA method driven by daily tower-specific meteorology decreased by more than 5 W/m2 for crop and grass sites, and by more than 6 W/m2 for forest, shrub, and savanna sites. The average coefficients of determination (R2) increased by approximately 0.05 for most sites. To test the BMA method for regional mapping, we applied it for MODIS data and GMAO-MERRA meteorology to map annual global terrestrial LE averaged over 2001–2004 for spatial resolution of 0.05°. The BMA method provides a basis for generating a long-term global terrestrial LE product for characterizing global energy, hydrological, and carbon cycles
No Evidence for XMRV Nucleic Acids, Infectious Virus or Anti-XMRV Antibodies in Canadian Patients with Chronic Fatigue Syndrome
The gammaretroviruses xenotropic murine leukemia virus (MLV)-related virus (XMRV) and MLV have been reported to be more prevalent in plasma and peripheral blood mononuclear cells of chronic fatigue syndrome (CFS) patients than in healthy controls. Here, we report the complex analysis of whole blood and plasma samples from 58 CFS patients and 57 controls from Canada for the presence of XMRV/MLV nucleic acids, infectious virus, and XMRV/MLV-specific antibodies. Multiple techniques were employed, including nested and qRT-PCR, cell culture, and immunoblotting. We found no evidence of XMRV or MLV in humans and conclude that CFS is not associated with these gammaretroviruses
- …